Sunday, March 24, 2013

'The Office' Finale: Cast Preview 'Big,' 'Emotional' Ending That Will Make You 'Laugh And Cry'

"The Office" only has seven episodes left before the series finale, and both the cast and the fans are gearing up to say goodbye to the Dunder Mifflin gang after almost a decade on our screens. But will it be a satisfying ending?

"I think the fans are going to be very happy," Angela Kinsey told TVLine at the show's finale party. "When we read the finale ... I was laughing and crying, and I think that's all you can hope for, to laugh and cry. I actually think there's a lot of laughs."

Showrunner Greg Daniels previewed that the finale would be "big," and said that he intended to "beg NBC" to allow him to supersize it to give fans plenty of bang for their buck.

"There are so many great characters that we all really cared about, so the biggest task was finding a story structure where they could have stories inside of it that would pay off and fit it all into the time frame," Daniels recently told EW. "These characters have been in my head taking up room for 10 years ? so it was personally important to me that I figure out what their end and closure was.?

Star Rainn Wilson had nothing but praise for Daniels' finale script, telling TVLine, "Greg Daniels, our showrunner ? has a really deft touch with dealing with real, deep and truthful emotion and just absurd wackiness. He balanced both of those very well in this final episode."

Last week, the show wrapped production for good, leading to some emotional tweets from the cast:

For more from "The Office" wrap party, head over to TVLine.

"The Office" airs Thursdays, 9 p.m. ET on NBC.

Related on HuffPost:

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Source: http://www.huffingtonpost.com/2013/03/22/the-office-finale-ending_n_2937514.html

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Saturday, March 23, 2013

How to remove a friend from Game Center on iPhone and iPad

How to remove a friend from Game Center on iPhone and iPad

If you use Game Center to play a lot of multiplayer games, you may start accumulating a lot of friends. If you start getting too many requests or just want to clean up your Game Center friends list a little, it's actually a pretty easy task.

Here's how:

  1. Launch the Game Center app from the Home screen of your iPhone or iPad.
  2. Tap on the Friends tab in the bottom navigation menu.
  3. Find the friend in the list that you'd like to remove and swipe sideways on their name.
  4. You'll notice an Unfriend button appear. Tap on it.

That's all there is to it. That person will no longer appear in your Game Center friends list and won't be able to send you game requests any longer.



Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/6yT-1MB93w4/story01.htm

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Harvard's 1st NCAA win brings 'unexpected pride'

Harvard Crimson guard Siyani Chambers (1) celebrates after the Crimson beat New Mexico in the NCAA tournament at EnergySolutions Arena on Thursday, March 21, 2013. (AP Photo/The Salt Lake Tribune, Scott Sommerdorf)

Harvard Crimson guard Siyani Chambers (1) celebrates after the Crimson beat New Mexico in the NCAA tournament at EnergySolutions Arena on Thursday, March 21, 2013. (AP Photo/The Salt Lake Tribune, Scott Sommerdorf)

Harvard's Siyani Chambers (1) celebrates with teammate Christian Webster, right, after defeating New Mexico 68-62 during a second-round game in the NCAA college basketball tournament in Salt Lake City Thursday, March 21, 2013. (AP Photo/Rick Bowmer)

Harvard's Kenyatta Smith (25), Laurent Rivard (0) Wesley Saunders (23) huddle in the second half during a second-round game against New Mexico in the NCAA college basketball tournament in Salt Lake City Thursday, March 21, 2013. (AP Photo/Rick Bowmer)

Harvard head coachTommy Amaker shouts to his team during a second-round game aginst New Mexico in the NCAA college basketball tournament in Salt Lake City Thursday, March 21, 2013. Harvard defeated New Mexico New Mexico 68-62. (AP Photo/Rick Bowmer)

Harvard players celebrate on the bench after beating New Mexico during a second round game in the NCAA college basketball tournament in Salt Lake City Thursday, March 21, 2013. Harvard beat New Mexico 68-62. (AP Photo/George Frey)

(AP) ? Michael Lesley crisscrossed Harvard Yard, looking up from his copy of David Hume's "The Natural History of Religion" only to avoid the tourists that shuffled through the snow-covered quadrangle.

Did he bother to watch Harvard's victory over No. 10 New Mexico on Thursday night, the first NCAA tournament win in school history?

No.

Will Lesley, a fourth-year doctoral student in religion, tune in when the Crimson play Arizona for a spot in the Sweet 16 on Saturday?

"Absolutely. Are you kidding me?" he said on Friday afternoon, a day after the Ivy League champions upset the third-seeded and heavily favored Lobos 68-62 in Salt Lake City.

"I think the attitude was, 'We'll see what happens,'" said Lesley, who followed the reaction to the game on Facebook. "To see everyone light up, it is exciting."

Harvard undergraduates are on spring break this week, so the dorm windows ringing the Yard were absent of the banners that usually herald, say, a big football game against Yale or a particularly avant-garde student production of a Samuel Beckett play. A day after the Crimson's unprecedented NCAA win, the centuries-old quad was bustling with guided tours in English, Japanese and Spanish but largely absent of students on their way to class.

That didn't stop the Harvard community from celebrating the victory.

"They did a good job, man, I'm happy for them," Houston Rockets point guard Jeremy Lin, the biggest basketball star to come out of Harvard, said after the NBA team's shootaround on Friday morning. "It's a great win. They made history."

Harvard President Drew Gilpin Faust was in Seoul giving a speech during the game, but a spokesman said she followed the second half closely and called coach Tommy Amaker to congratulate the team and wish them luck in the next round.

Senior Molly Stansik, who was flagged down in her dormitory courtyard, said she missed the game because she flying back from a spring break trip to Puerto Rico on Thursday night. But there were eight or nine other Harvard students on the plane, and one of them was able to stream the basketball game on his computer.

"I could hear him across the plane," Stansik said. "Everyone was screaming and reacting accordingly."

Although the campus was quiet, Lesley watched as the students bonded over social media. "Everyone's rather thrilled," he said.

"At a place like this, people are talking about the first win in 377 years, as if basketball has been around as long," Lesley said with a chuckle. "There's just a lot of unexpected pride."

The oldest and perhaps the most prestigious university in the nation, Harvard has produced a handful of U.S. presidents, dozens of Nobel Laureates and enough bankers, lawyers and politicians (and comedy writers) to prompt the Harvard Lampoon to tweet after the game: "America, we are sorry for messing up your brackets and also your financial system and everything else."

The Crimson football team won the Rose Bowl in the leather-helmet days and famously tied Yale in 1968, and the Harvard rowers can hold their own against Oxford and Cambridge in the Henley Regatta. The school has placed first in the annual U.S. News & World Report academic rankings for five consecutive years.

But, until recently, Harvard has had little to brag about in basketball.

Then Lin emerged as an NBA star in 2011, when the Crimson also won a share of their first-ever Ivy League men's basketball title. And, last year, they won the conference championship outright to earn a spot in the NCAA tournament for the first time since 1946. (They lost to Vanderbilt 79-70.)

The chances of a repeat were said to be doomed when Harvard's senior co-captains withdrew from school last fall in the wake of a plagiarism investigation. But senior Christian Webster, who played little last year, and freshman Siyani Chambers emerged to lead the Crimson to a third straight Ivy title.

Harvard was such an underdog that only 4.5 percent of the more than 3 million brackets collected by Yahoo Sports picked Harvard to beat New Mexico. But the Crimson pulled off the biggest surprise of the tournament's first full day, knocking out the Mountain West champions and earning the school's first-ever victory over a team ranked in The Associated Press Top 10.

"They had a rough year, losing the two team captains and relying a lot on freshmen and sophomore players," said Lin, who graduated in 2010 and never made it to the NCAAs. "It's just pretty cool."

And maybe now Harvard is, too.

"You could tell, even last night, just everyone saying 'nerd, geek, whatever, whatever, whatever,'" Lin said. "All that stuff, they keep saying it and, yeah, it's a joke. But I think eventually people will realize that even though you go to Harvard, you can still hoop."

___

Follow Jimmy Golen on Twitter at http://twitter.com/jgolen

___

AP Sports Writer Chris Duncan contributed to this story from Houston.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-03-22-BKC-NCAA-Hail-Harvard/id-49e5be914fa94fedb55ed31f4e2cde37

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Nanoose Arts | Entertainment, Sports | Recreation | Spring Break ...

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Friday, March 22nd, 2013
Rookie Camp 10am - 10:45am Learn to Play 11am - 12pm

All sessions feature games and activities that allow kids to see measurable progress while having fun competing, learning, and relating with other kids of similar experience and abilities.

Class size is a maximum of 8 participants per instructor. Minimum 3 students. Classes are held rain or shine. Equipment is provided, but participants are encouraged to bring their own.

Rookie (ages 5-7)
Your child will learn the fundamental skills of golf that include grip, stance, balance and swing for putting, chipping and full swing, basic rules, and etiquette. All sessions feature games and activities that are tailored to stages of mental and physical development for this age group.

Dates: March Spring Break
Monday, March 18
Wednesday, March 20
Friday, March 22

Time: 10:00 am - 10:45 am

Instructor: H?l?ne Delisle

Cost: $45 - three 45 minute lessons

Learn to Play (ages 8-12)
One of the most important periods of motor development for children is between the ages of 9 and 12. At this stage, children are developmentally ready to acquire general sports skills that are the cornerstones of all athletic development.

Your child will learn key concepts, grip, stance, posture, alignment, and balance of the long and short game.

Dates: March Spring Break
Monday, March 18
Tuesday, March 19
Wednesday, March 20
Thursday, March 21

Time: 11:00 am - 12:00 pm

Instructor: H?l?ne Delisle

Cost: $75 - four one hour lessons

All programs are held at Fairwinds driving range. Space is limited. Call 250.468.7666 or toll free 1.888.781.2777 for more information.

Source: http://www.harbourliving.ca/event/spring-break-junior-golf-camp/2013-03-22/

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Former chef who cooked wife's body gets 15 years to life in prison

By Jason Kandel, NBCLosAngeles.com

A former chef who killed his wife and cooked her body for four days to dispose of her remains was sentenced on Friday to 15 years to life in prison.

David Robert Viens, 49, was convicted of second-degree murder for the slaying of his wife, Dawn, in 2009.

Before Viens was sent back into custody, the victim's sister, Dayna Papin, urged the court to continue to keep Viens locked up.

See original story at NBCLosAngeles.com

"He's going to continue to fight for his freedom, which I hope you don't give to him for a very long time," Papin said.


Viens attended his court proceedings in a wheelchair as a result of injuries suffered when he jumped 80 feet down Inspiration Point in Rancho Palos Verdes on Feb. 23, 2011, after a Los Angeles County sheriff's deputy tried to stop his vehicle and Viens' girlfriend tried to stop him from plunging from the oceanfront cliff by grabbing his clothes.

Viens said he argued with his wife and bound her mouth, hands and feet with duct tape because he didn't want her going out driving while intoxicated, prosecutors said.

After he found her dead the next morning, he concocted a plan to cook her remains, prosecutors said.

"I took some, some things like weights that we use and I put them on the top of her body, and I just slowly cooked it and I ended up cooking her for four days," Viens said, according to audio released in court from an interview with deputies.

Defense attorneys argued that Viens did not intend to kill his wife.

Dawn Viens was reported missing by friends and family members three weeks after she was last seen at the couple?s Lomita restaurant, the Thyme Contemporary Caf?, in October 2009.

Source: http://feeds.nbcnews.com/c/35002/f/653381/s/29e3365d/l/0Lusnews0Bnbcnews0N0C0Inews0C20A130C0A30C220C174198710Eformer0Echef0Ewho0Ecooked0Ewifes0Ebody0Egets0E150Eyears0Eto0Elife0Ein0Eprison0Dlite/story01.htm

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New method developed to expand blood stem cells for bone marrow transplant

Mar. 21, 2013 ? More than 50,000 stem cell transplants are performed each year worldwide. A research team led by Weill Cornell Medical College investigators may have solved a major issue of expanding adult hematopoietic stem cells (HSCs) outside the human body for clinical use in bone marrow transplantation -- a critical step towards producing a large supply of blood stem cells needed to restore a healthy blood system.

In the journal Blood, Weill Cornell researchers and collaborators from Memorial-Sloan Kettering Cancer Center describe how they engineered a protein to amplify adult HSCs once they were extracted from the bone marrow of a donor. The engineered protein maintains the expanded HSCs in a stem-like state -- meaning, they will not differentiate into specialized blood cell types before they are transplanted in the recipient's bone marrow.

Finding a bone marrow donor match is challenging and the number of bone marrow cells from a single harvest procedure are often not sufficient for a transplant. Additional rounds of bone marrow harvest and clinical applications to mobilize blood stem cells are often required.

However, an expansion of healthy HSCs in the lab would mean that fewer stem cells need to be retrieved from donors. It also suggests that adult blood stem cells could be frozen and banked for future expansion and use -- which is not currently possible.

"Our work demonstrates that we can overcome a major technical hurdle in the expansion of adult blood stem cells, making it possible, for the first time, to produce them on an industrial scale," says the study's senior investigator, Dr. Pengbo Zhou, professor of pathology and laboratory medicine at Weill Cornell.

If the technology by Weill Cornell passes future testing hurdles, Dr. Zhou believes bone marrow banks could take a place alongside blood banks.

"The immediate goal is for us to see if we can take fewer blood stem cells from a donor and expand them for transplant. That way more people may be more likely to donate," Dr. Zhou says. "If many people donate, then we can type the cells before we freeze and bank them, so that we will know all the immune characteristics. The hope is that when a patient needs a bone marrow transplant to treat cancer or another disease, we can find the cells that match, expand them and use them."

Eventually, individuals may choose to bank their own marrow for potential future use, Dr. Zhou says. "Not only are a person's own blood stem cells the best therapy for many blood cancers, but they may also be useful for other purposes, such as to slow aging."

A Scrambled Destruction Signal

Bone marrow is the home of HSCs that produce all blood cells, including all types of immune cells. One treatment for patients with blood cancers produced by abnormal blood cells is to remove the unhealthy marrow and transplant healthy blood stem cells from a donor. Patients with some cancers may also need a bone marrow transplant when anticancer treatments damage the blood. Bone marrow transplantation can also be used to treat other disorders, such as immune deficiency disorders.

The process of donating bone marrow, however, can be arduous and painful, requiring extraction of marrow with a needle from a large bone under general anesthesia. A donor may also need to undergo the procedure multiple times in order to provide enough stem cells for the recipient.

Because of these issues of extracting donor bone marrow, there have been a number of attempts to expand HSCs that have focused on the transcription factor HOXB4, which stimulates HSCs to make copies of themselves. "The more HOXB4 protein there is in stem cells, the more they will self-renew and expand their population," Dr. Zhou says.

But all previous efforts are limited in their applicability. HSCs are notoriously refractory to gene transfer. Virus-based vehicles are thus far the most efficient means to deliver therapeutic genes into HSCs in the laboratory setting. In the past, scientists used a virus as a vehicle to deliver a therapeutic gene into patients with severe combined immunodeficiency disease (SCID) to correct their immune deficiency. However, four children receiving SCID gene therapy developed treatment-related leukemia due to the inability to control where the virus inserts itself in the genome, often on the so-called "hot spots" that activate oncogenes or inactivate tumor suppressor genes. Also, other investigators have shown that it is possible to directly insert HOXB4 protein into extracted bone marrow stem cells. "All you do is add a little tag to the protein, which acts like a vehicle, driving the proteins through the cell membrane, directly into the nucleus," Dr. Zhou says. "But the half-life of the natural protein is very short -- about one hour. So that means that in order to expand blood stem cells, these HOXB4 proteins have to be added all the time. Because the proteins are very costly, this process is both expensive and impractical."

Dr. Zhou and his team, in collaboration with Dr. Malcolm A. S. Moore's group from Memorial Sloan-Kettering Cancer Center, took a different approach. They examined why HOXB4 protein doesn't last long in HSCs, once these cells are removed from the protective stem cell niche that they nest quietly in. They found that HOXB4 is targeted for degradation so that stem cells can start differentiating -- that is, turn into different kinds of adult blood cells. "HOXB4 prevents blood stem cells from differentiating, while, at the same time, allows them to renew themselves," Dr. Zhou says.

The researchers found that a protein, CUL4, is tasked with recognizing HOXB4 and tagging it for destruction by the cell's protein destruction apparatus. They discovered that CUL4 recognizes HOXB4 because it "sees" a set of four amino acids on the protein. "HOXB4 carries a destruction signal that CUL4 recognizes and acts on," Dr. Zhou says.

The research team engineered a synthetic HOXB4 protein with a scrambled destruction signal. They produced large quantities of the protein in bacteria, and then delivered the protein into human blood stem cells in the laboratory. "When you mask the CUL4 degradation signal, HOXB4's half-life expands for up to 10 hours," Dr. Zhou says. "The engineered HOXB4 did its job to expand the stem cell, while keeping all its stem cell properties intact. As a result, cells receiving the engineered HOXB4 demonstrated superior expansion capacity than those given natural HOXB4 protein. Animal studies demonstrated that the transplanted engineered human stem cells can retain their stem cell-like qualities in mouse bone marrow."

Dr. Zhou says the engineered protein HOXB4 can potentially be administered every 10 hours or so to make the quantity of blood stem cells necessary for patient transplant and for banking. "This is the ultimate goal for what we are trying to achieve," he says. "There are likely many roadblocks ahead to reach our goals, but we appear to have found ways to deal with one major hurdle of adult hematopoietic stem cell expansion."

Cornell Center for Technology Enterprise and Commercialization (CCTEC), on behalf of Cornell University, has filed a patent application that covers the work described here. Other co-authors include Dr. Jennifer Lee, Dr. Jianxuan Zhang, Dr. Liren Liu, Dr. Yue Zhang, and Dr. Jae Yong Eom from Weill Cornell Medical College; Dr. Giovanni Morrone from the University of Catanzaro "Magna Graecia," Catanzaro, Italy; and Dr. Jae-Hung Shieh from the Cell Biology Program, Memorial Sloan-Kettering Cancer Center.

The study was supported by grants from the National Institutes of Health (CA118085, CA098210 and NIHA12008023), the Leukemia and Lymphoma Society Scholar Award and the Irma T. Hirschl Career Scientist Award.

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/uXU_eBShvYg/130321151923.htm

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Kay's workers' comp bills receive testimony, no vote | Madison Record

Kay

Kay

Rep. Dwight Kay, R-Glen Carbon, on Wednesday presented four bills aimed at reforming the state?s workers? compensation system.

Similar to his asbestos ?double-dipping? measure that was heard in the House Judiciary Committee earlier this month, Kay?s workers? comp bills were not called to a vote, but did garner brief testimony in the Labor & Commerce Committee. It is unclear when, or if, they will be called to a committee vote.

The bills Kay presented to the committee this week ? House Bills 1245, 1246, 2229 and 2769 ? represent four of nine measures he introduced this session that deal with the state?s workers comp system.

They are also part of a larger GOP-backed ?pro-growth jobs? legislative package that proposes changes to the tort and tax systems, as well to the state?s regulations on businesses, in attempt to create more jobs and make Illinois more competitive with its neighboring states.

If the battle over workers? comp reform that took place in 2011 is any indication, Kay?s measures will likely face some resistance.

The four bills he presented this week received mixed reactions as groups like the Illinois Trial Lawyers? Association (ITLA) and Associated Fire Fighters of Illinois (AFFI) voiced opposition to some while business groups and associations that represent municipalities offered their support on others.

The ITLA and AFFI, as well as a few other groups, voiced opposition to HB2229, which would amend the Workers? Compensation and the Workers? Occupational Diseases acts to create ?certain rebuttable presumptions regarding certain conditions of a firefighter, emergency medical technician (EMT), or paramedic.?

Among other changes, HB2229 would add language to the acts to make their provisions applicable to an EMT or paramedic cross-trained as a firefighter, instead of any EMT or paramedic.

Kay told that committee that under current law, EMT?s are categorized the same as firefighters for the purpose of buying workers? comp insurance. His bill would also delete language that includes blood borne pathogens and tuberculosis as conditions to which those provisions apply to.

?I feel like that?s unjust because EMT?s do nothing like firefighters,? he said.

Eddy Crews, a legislative representative for the AFFI, testified that his group is ?adamantly opposed? to Kay?s bill.

He said his group is currently negotiating a similar bill in the Senate sponsored by Senate Minority Leader Christine Radogno, who Crews said, asked the AFFI to consider language to address concerns of a certain private ambulance company.

In response, Kay said he is unaware of any Illinois EMT who has died in the line of duty and that categorizing EMT?s the same way as firefighters places ?an undue burden? on counties and villages throughout the state.

?Quite frankly, it makes no sense to me whatsoever,? Kay said, adding that municipalities are ?paying five times the amount they should for workers? comp insurance and I think that?s wrong.?

Kay also presented HB2769 to the committee this week. This bill would change the way compensation is computed when an employee making a workers? comp claim sustained a previous injury that resulted in the payment of compensation for a percentage of partial disability.

Under HB2769, the previous percentage of partial disability would be deducted from any award for a subsequent injury to the same portion of the body that was involved in the prior injury.

In addition to other changes,Kay?s bill states that ?nothing in those provisions permits cumulative awards for compensation for partial disability to exceed 500 weeks, which shall constitute complete loss of use of the body as a whole.?

Kay said his legislation aims to correct the results of ?a bad decision that came out of arbitration in Northern Illinois? in the case of Will County Forest District v. Illinois Workers? Compensation Commission.

?In short, what we are ending up with here are arbitrators who are extending man-as-a-whole beyond 100 percent,? he said. ?That?s a very dangerous situation.?

Margo Ely, director of legal, human resources and risk management for the City of Naperville, testified in support of Kay?s measure. Other supporters of HB2769 include the Illinois Municipal League and the National Federation of Independent Businesses.

Ely told the committee that the City of Naperville has more than 900 employees and spends about $1.5 million a year on compensation, either in time off, medical expense payments and lump sum settlements.

Workers? compensation, she said, ?is not supposed to be lucrative. It?s supposed to just make them whole.?

?This particular bill is a step in the right direction,? she said.

Kay also briefly discussed House Bills 1245 and 1246.

HB1245 would provide that appeals over decisions of the Workers? Compensation Commission on compensation of a state employee?s claim could be made in circuit court.

HB1246 would require the Department of Central Management Services to charge the employing state agency for workers? compensation payments for medical expenses and temporary total disability paid to an employee. Current law only does this in certain situations dealing with temporary total disability payments.

Legislation can found on the Illinois General Assembly?s website at ilga.gov.

Source: http://madisonrecord.com/news/253981-kays-workers-comp-bills-receive-testimony-no-vote

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