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Source: http://feedproxy.google.com/~r/Techcrunch/~3/IUb4It4FgbQ/
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July 1, 2013 ? DNA fragments in your blood may someday help doctors quickly learn if chest pain means you have narrowed heart arteries, according to a new study published in the American Heart Association journal Arteriosclerosis, Thrombosis, and Vascular Biology.
The study involved 282 patients, ages 34 to 83, who reported chest pain and were suspected of having coronary artery disease. Researchers used computed tomography imaging to look for hardened, or calcified, buildup in the blood vessels that supply the heart. Blood samples also were tested for bits of genetic material. Release of small DNA particles in the blood occurs during chronic inflammatory conditions such as coronary artery disease.
Higher levels of DNA particles in the blood were linked to high levels of coronary artery calcium deposits. These particles are potentially markers of disease, and may eventually help identify patients with severely narrowed coronary arteries, predict how many coronary vessels were affected, and even whether a patient is likely to suffer a serious heart problem or heart-related death.
"If those markers are proven to be effective -- specific and sensitive -- they may improve medical care in terms of identifying patients at risk sooner," said Julian Borissoff, M.D., Ph.D., lead author of the study and postdoctoral research fellow at Boston Children's Hospital and Harvard Medical School. "And so the patients may go on treatment sooner."
The scientists noted that larger studies, following more patients for longer periods, are needed to see how precisely these markers might identify patients at risk for developing coronary artery disease. Almost half of the patients studied were followed for a year and a half or longer.
If the markers do pan out, they have the potential to help doctors efficiently pinpoint which patients with chest pain are likely to have coronary artery disease rather than some other problem causing the discomfort, Borissoff said. Currently, a time-consuming and costly battery of tests is used to determine whether the heart is at risk, he said.
It is plausible to think that the DNA particles themselves might contribute to the progression of atherosclerosis and the risk of dangerous blood vessel blockages, the study's authors wrote. "The more the ongoing cell death, which is normal with inflammation, the more DNA enters the circulation and more plaque builds up," Borissoff said. "Cells get damaged, and the products released from the damaged cells can cause even more damage and inflammatory responses."
The researchers are testing the DNA particle components further, he said, to see which ones are most sensitive and to understand more about how their levels might vary -- for instance, during different stages of progression of atherosclerosis, or during a treadmill test, or after treatment for a heart attack.
Co-authors are Ivo A. Joosen, M.D., Mathijs O. Versteylen, M.D.; Alexander Brill, M.D., Ph.D.; Tobias A. Fuchs, Ph.D.; Alexander S. Savchenko, M.D., Ph.D.; Maureen Gallant, B.S.; Kimberly Martinod, B.A., B.S.; Hugo ten Cate, M.D., Ph.D.; Leonard Hofstra, M.D., Ph.D.; Harry J. Crijns, M.D., Ph.D.; Denisa D. Wagner, Ph.D.; Bas L.J.H. Kietselaer, M.D., Ph.D.
The Netherlands Heart Foundation supported the study.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/rYraUEgjFvE/130701080933.htm
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Google has delivered a steady stream of Glass updates since the Explorer Edition launched, but its new July upgrade may be the biggest yet -- it addresses several of our earliest gripes. Wearers can now answer phone calls or have messages read aloud. It's also now possible to call or message any Gmail contact, not just the top ten. Oh, and that hidden web browser? It's now public: Glass owners can ask to see a favorite page and navigate using the touchpad. If you're one of the precious few to sport Google's eyewear, you should automatically receive the much-improved firmware in the next few days; we've already heard of at least one user getting the upgrade today.
Update: We now have screenshots of how browsing works in the update -- check them out below.
Filed under: Wearables, Google
Source: Project Glass (Google+)
Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/OqSR-i-p77U/
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Opponents of Egypt's Islamist President Mohammed Morsi protest outside the presidential palace in Cairo, Egypt, Sunday, June 30, 2013. Hundreds of thousands of opponents of Egypt's Islamist president poured out onto the streets in Cairo and across much of the nation Sunday, launching an all-out push to force Mohammed Morsi from office on the one-year anniversary of his inauguration. Fears of violence were high, with Morsi's Islamist supporters vowing to defend him. (AP Photo/Nariman El-Mofty)
Opponents of Egypt's Islamist President Mohammed Morsi protest outside the presidential palace in Cairo, Egypt, Sunday, June 30, 2013. Hundreds of thousands of opponents of Egypt's Islamist president poured out onto the streets in Cairo and across much of the nation Sunday, launching an all-out push to force Mohammed Morsi from office on the one-year anniversary of his inauguration. Fears of violence were high, with Morsi's Islamist supporters vowing to defend him. (AP Photo/Nariman El-Mofty)
CAIRO (AP) ? Hundreds of thousands of Egyptian marched in the streets Sunday demanding the removal of President Mohammed Morsi on the anniversary of his inauguration, with his Islamist backers vowing to defend him.
Here are some key events from more than two years of turmoil and transition.
Jan. 25-Feb. 11, 2011 ? Egyptians stage nationwide demonstrations against the rule of autocrat Hosni Mubarak, who led the country for nearly three decades. The 18-day "revolution," launched by secular and leftist youth, draws in a wide spectrum, including the Muslim Brotherhood and other Islamists. Hundreds of protesters are killed as Mubarak and his allies try to crush the uprising.
Feb. 11 ? Mubarak steps down and turns power over to the military. Two days later, the body of top generals, the Supreme Council of the Armed Forces, dissolves parliament and suspends the constitution, meeting two key demands of protesters.
March 19 ? In the first post-Mubarak vote, Egyptians cast ballots on constitutional amendments sponsored by the military setting the framework for the transition to democracy, including scheduling the first parliamentary and presidential elections. Islamists back the amendments, eager to hold elections they are poised to dominate. Many revolutionaries push for a "no" vote, arguing a constitution should be written first. The measures are overwhelmingly approved.
Oct. 9 ? Military troops crush a protest by Christians in Cairo over a church attack, killing more than 25 protesters. The rally as among many during the military's nearly 17-month rule, with protesters often calling for the removal of the generals and clashes frequently erupting that killed dozens
Nov. 28, 2011-Feb 15, 2012 ? Egypt holds multistage, weekslong parliamentary elections, with Islamists scoring big. In the lawmaking lower house, the Muslim Brotherhood wins nearly half the seats, and ultraconservative Salafis take another quarter. The remainder goes to liberal, leftist, independent and secular politicians. In the largely powerless upper house, few voters bother to cast ballots, and Islamists take nearly 90 percent of the seats.
May 23-24, 2012 ? The first round of voting in presidential elections, with a field of 13 candidates. Morsi and Ahmed Shafiq, the last prime minister under Mubarak, emerge as winners to face each other in a runoff.
June 14 ? The Supreme Constitutional Court orders the dissolving of the Islamist-dominated lower house of parliament on grounds that a third of its members were elected illegally. The military swiftly closes down parliament.
June 16-17 ? Egyptians vote in the presidential runoff between Morsi and Shafiq. The generals issue a "constitutional declaration" giving themselves sweeping authorities and limiting the powers of the next president. Morsi emerges as the victor, with 51.7 percent of the vote.
June 30 ? Morsi takes his formal oath of office before the Supreme Constitutional Court, a day after reading a symbolic oath in Cairo's Tahrir Square, birthplace of the revolution.
Aug. 12 ? In a bold move, Morsi orders the retirement of the top Mubarak-era leadership of the military and cancels the military's last constitutional decree, taking back the powers that the generals gave themselves. The move was seen as way to curb the military's role in political affairs but it also gave Morsi the power to legislate in the absence of parliament.
Nov. 19 ? Members of liberal parties and representatives of Egypt's churches withdraw from the 100-member assembly writing the constitution, created by parliament before it was dissolved. They say they are protesting attempts by Islamists who dominate the panel to impose their will on the draft.
Nov. 22 ? Morsi unilaterally decrees greater authorities for himself, giving his decisions immunity from judicial review and barring the courts from dissolving the constituent assembly and the upper house of parliament. The move came just ahead of court decisions that could have dissolved the bodies. The move sparks days of protests, with clashes between Morsi's supporters and opponents. At one point, some 200,000 people rally in Tahrir Square, with some of the first chants for Morsi to "leave."
Nov. 30 ? In a marathon, all-night session, Islamists on the constituent assembly rush to complete the draft of the constitution, with non-Islamists almost completely boycotting the gathering. Morsi sets a Dec. 15 date for a referendum, further fueling protests.
Dec. 2 ? Islamists protest outside the Supreme Constitutional Court, blocking judges from entering to rule on the legality of the constituent assembly.
Dec. 4 ? More than 100,000 protesters march on the presidential palace, demanding the cancellation of the referendum and the writing of a new constitution. The next day, Islamists attack a peaceful anti-Morsi sit-in outside the palace, sparking all-out street battles that leave at least 10 dead. Days later, Morsi rescinds his initial decrees, but maintains the date of the referendum.
Dec. 15, Dec. 22 ? In the two-round referendum, Egyptians approve the constitution, with 63.8 percent voting in favor. Turnout, however, is low with only 32.9 percent of voters participating.
Dec. 29 ? The Egyptian Central Bank announces that foreign reserves ? drained to $15 billion from $36 billion in 2010 ? have fallen to a "critical minimum" and starts new measures to stop a sharp slide in the value of the Egyptian pound. The pound's decline slows but doesn't stop, and now stands at just over 7 to the dollar, compared to as strong as 5.5 to the dollar in 2010.
Jan. 25, 2013 ? Hundreds of thousands hold protests in Tahrir Square and nationwide against Morsi on the 2-year anniversary of the start of the revolt against Mubarak, and clashes erupt in many places. The following day, residents of the city of Port Said stage protests, angered by a court ruling convicting and sentencing to death a group of local soccer fans for a 2012 stadium riot. Police crack down hard in Port Said, killing more than 40 protesters, and in outrage the city and others nearby go into near revolt. Much of the anger is focused at Morsi, who praised the police for their crackdown.
Feb. 22 ? Morsi schedules elections for a new lower house of parliament, to begin in April. But the election is postponed after a court rules that the upper house ? which is carrying out legislative duties until a lower house is created ? improperly approved the law governing the election. It remains unknown when elections will be held.
Feb.-March 2013 ? Protests continue in Port Said and other cities for weeks, with dozens more dying in clashes, and some police units around the country go on strike. Brotherhood youth and their opponents fight in the streets outside the group's main Cairo headquarters.
April 7 ? A Muslim mob attacks the main cathedral of the Coptic Orthodox Church when Christians hold a funeral and protest there over four Christians killed in sectarian violence outside of Cairo the day before. One person is killed in clashes at the cathedral, and Pope Tawadros II publicly blames Morsi for failing to protect the building, thought the president condemns the attack.
May 7 ? Morsi reshuffles the Cabinet, bringing in more ministers from the Muslim Brotherhood to total 11 members of the 36-member government. Officials say the changes aim to finalize long-stalled negotiations with the International Monetary Fund for crucial $4.8 billion loan, which requires sensitive reductions to fuel and food subsidies that take up a large chunk of the budget. A deal has still not been reached.
June 23 ? A mob beats to death four Egyptian Shiites in their home in a village on the edge of Cairo. Morsi condemns the attack, but critics blame virulent anti-Shiite rhetoric by his hard-line Islamist allies, fueled by Syria's civil war. A week earlier, Morsi shared a stage with hard-line clerics at a rally, sitting silently as they denounced Shiites as "filthy."
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The death of Google Reader (we move on)
www.liveside.netWell, nothing like waiting til the last minute. Tomorrow (July 1st), Google will shut down Google Reader, which as you may know we?ve been using to aggregate our list of feeds for ?Blogs We Like?. While a number of new ? Continue reading ?
Source: http://www.facebook.com/liveside/posts/10151728824513529
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June 30, 2013 ? A protein first shown to function in the liver plays a crucial role in pregnancy in mice and has a key role in the human menstrual cycle, according to researchers at the University of Montreal. Mice that were genetically engineered not to produce the liver receptor homolog-1 (Lrh-1) molecule were unable to create the uterine conditions necessary for establishing and sustaining pregnancy, resulting in the formation of defective placentas. The researchers then showed that Lhr-1 was present in the human uterus and the essential processes related to the success of early gestation.
"We previously showed that Lrh-1 is essential for ovulation. Our newest studies have revealed that it is plays an important role in the uterus, raising the possibility that Lrh-1 deficiency contributes to human gestational failure," explained lead author Bruce Murphy, of the university's Animal Reproduction Research Centre. "We worked with mice before looking at human tissues. I believe it premature to propose determination of Lrh-1 in uterine biopsies as a diagnostic tool, but we are working on determining the receptor's pattern of expression across the menstrual cycle."
The researchers also looked at whether hormone replacement therapy might restore normal uterine functions in the mice. "Progesterone did not make a difference. Although hormone therapy allowed for the embryos to implant, we saw problems with the lining in the uterus, compromised formation of the placenta, fetal growth retardation and fetal death," Murphy said. "However, there are new Lrh-1 agonists and antagonists, currently in clinical trials to treat hepatic consequences of type II diabetes, and thus therapeutic intervention might be possible."
The study was published in Nature Medicine on June 30, 2013, and was funded by the Canadian Institutes of Health Research. The US National Institutes of Health funded collaborators at Baylor University that contributed to the study.?
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The above story is reprinted from materials provided by Universite de Montreal, via Newswise.
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/XMMTwWhUK3A/130630144447.htm
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SAN DIEGO (AP) ? Robert and Emerald Oravec were itching to sell their condominium late last year to move closer to a favorite surfing spot, but they were stuck. They owed the bank $194,000 and figured the most they could get was $180,000.
When they put their San Diego home up for sale a few months later, they fielded five offers within two weeks. It sold for $260,000 in May, allowing them to invest profits in a new home that's more than twice the size on a large lot and 40 minutes closer to the surfing beach.
"We're stoked," said Robert, 50, a facilities engineer at Solar Turbines Inc., a maker of gas turbines that has employed him for the last 22 years. "It was better to be patient and wait it out."
Soaring prices are leaving fewer homeowners owing more money than their properties are worth, bringing them off the sidelines of the nation's surging housing market and offering relief to buyers who are frustrated by bidding wars. As more homes are put up for sale, price increases are expected to moderate.
Mark Fleming, chief economist at real estate data provider CoreLogic Inc., calls it "a virtuous circle."
"The fact that house prices have increased so dramatically ... has unlocked a lot of that pent-up supply," said Fleming, whose firm found that markets with the largest percentage of "underwater" or "upside down" mortgages often have the lowest supply of homes for sale.
From January to March, 19.8 percent of the nation's mortgaged homes were underwater, down from 23.7 percent a year earlier and 25 percent during the same period of 2011, according to CoreLogic. Gains spread across the country, though regions that rose high and crashed hard remained saddled with homeowners who bought near the peak.
Nevada had a nation-high 45.4 percent of mortgages underwater, followed by Florida at 38.1 percent, Michigan at 32 percent and Arizona at 31.4 percent. Montana had a nation-low 5.6 percent.
Among major metropolitan areas, Tampa Bay had a nation-high 41.1 percent of mortgaged homes underwater, followed by Miami at 40.7 percent. Dallas had a nation-low 8.3 percent.
San Diego, at 19.5 percent, was slightly better than the national rate and California's 21.3 percent. The region's median home sale price hit $406,500 in May, up 21.3 percent from a year earlier amid brisk sales, according to DataQuick.
Housing inventories remain unusually low. There was a 5.2-month supply of existing, single-family homes for sale in May, compared to 6.4 months a year earlier, according to the National Association of Realtors. California had only a 2.6-month supply, compared to 3.6 months a year earlier and well below the six months that is considered a balanced market.
San Diego broker Colleen Cotter began knocking on doors this year after scouring property records to find homeowners who didn't owe money. If someone answers, she makes an all-cash bid on behalf of investors who don't even visit.
Nearly one of three homes sold in Southern California is paid for in cash, putting borrowers at a disadvantage. Some buyers write sellers about how they would cherish a home, hoping to spark a personal connection.
Josh Martin, 26, discovered homes he and wife considered buying had changed hands less than a year earlier at much lower prices. The first-time homebuyers lost nine bids since August? many to cash buyers ? until finally landing a home in May for $250,000 in the San Diego suburb of Chula Vista.
"It was very stressful because the prices just kept going up," said Martin, who recently left the Marine Corps. "Our lease was about to end and we didn't want to sign another year."
Economists expect many homeowners will continue to resist selling because they think they can profit more by waiting.
Nancy Randazzo, a 38-year-old public school teacher who owes about $240,000 on an Anaheim condominium that she bought for $335,000 in 2005, figures she might be able to sell for what she owes but wants to rent to Disneyland tourists. One potential snag is that she and her fiancee would need to find a place to buy.
"Prices are going up so fast that I don't know if I can," she said.
The huge price increases produced an unexpected retirement gift for Larry and Diane Plaster, who were resigned in January to selling their San Diego home for less than they owed the bank, known as a short sale. They owed $352,000 but accepted an offer for $290,000.
Their bank rejected the deal four months later, leading the couple to put the home up for sale again. On the second attempt, they took an all-cash offer of $380,000, yielding a windfall of $6,500 after broker fees and closing costs. The Plasters, who live on Social Security income, fulfilled a dream of moving to a geodesic dome they built in Janesville, 130 miles north of Lake Tahoe.
The former Catholic social service workers were so angry when Chase rejected the short sale that they closed their account after more than 40 years.
"Now I guess I should send them a thank-you note," said Diane, 66.
Source: http://news.yahoo.com/home-price-gains-bring-sellers-off-sidelines-140703042.html
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